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However, one should keep in mind that with a very few exceptions, a real protein (not necessary an IDP) has a very sophisticated structural organization characterized by an intricate spatiotemporal heterogeneity, akin to a mosaic or a kaleidoscope, encompassing different functional units with various levels of disorderedness: foldons (independently foldable units), inducible foldons (IDRs that fold upon binding partners), inducible morphing foldons (IDRs that fold differently upon binding to different partners), non-foldons (non-folded regions essential for function), semi-foldons (always partially folded), and unfoldons (ordered regions that must unfold to become active) (Uversky, 2013c;a;b;Jakob et al., 2014)

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DOI: 10.1016/S0140-6736(19)31150-X [Google Scholar] Martinez Leon V, Hilburg R, Susztak K

Medication can help prevent the formation of gallstones, but surgery, typically the removal of the gallbladder, is sometimes necessary

This procedure operates on the principle of reconstituting a healthy microbial equilibrium in a recipients intestine by transferring processed fecal material from a rigorously screened healthy donor (537)